Mapping the “herbalome”
Chinese scientists are studying Chinese herbs to map all the compounds used in traditional Chinese medicine:
“The Herbalome Project is the latest–and most ambitious–attempt to modernize t raditional Chinese medicine (TCM). The venerable concoctions–as many as 400,000 preparations using 10,000 herbs and animal tinctures–are the treatment of choice and often the only recourse for many in China. In the 1970s, TCM tipped off researchers to qinghaosu, a compound in sweet wormwood whose derivatives are potent antimalaria drugs. But TCM’s reputation has been blackened by uneven efficacy and harsh side effects, prompting critics to assail it as outmoded folklore. “TCM is not based on science but based on mysticism, magic, and anecdote,” asserts biochemist Fang Shi-min, who as China’s self-appointed science cop goes by the name Fang Zhouzi. He calls the Herbalome Project “a waste of research funds.”
Hoping to rebut TCM critics, Herbalome will use high-throughput screening, toxicity testing, and clinical trials to identify active compounds and toxic contaminants in popular recipes. “We need to ensure that TCM is safe and also show that it is not just qinghaosu,” says Guo De-an, who leads TCM modernization efforts at the Shanghai Institute of Materia Medica and is not involved in Herbalome. Initial targets are cancer, liver and kidney diseases, and illnesses that are difficult for Western medicine to treat, such as diabetes and depression.”

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